New Directions in Infant Nutrition: Prebiotics
and Probiotics for Improving GI Health and Immunity

1 AMA PRA Category 1 Credit™,  
1 Nursing Contact Hour,
1 Hour Pharmacy CE*,
1 CPEU for Registered Dieticians.

Release date: November 12th, 2008
Expiration date: November 11th, 2011

Faculty

Ekhard Ziegler, M.D.
Professor of Pediatrics
University of Iowa Children’s Hospital
Iowa City, IA

Josef Neu, M.D.
Professor, Department of Pediatrics
Division of Neonatology
University of Florida College of Medicine
Gainsville, FL

Philip Sherman, M.D., FRCPC, FAAP
Professor of Pediatrics, Microbiology and Dentistry
Hospital for Sick Children
University of Toronto
Toronto, Canada

Target Audience
Physicians, Nurse Practitioners, Physician Assistants, Registered Nurses, Pharmacists, and Registered Dieticians.

Sponsor
Jointly sponsored by &

Funding
Supported, in part, through a restricted educational grant from Abbott Nutrition, a division of Abbott Laboratories, Inc.

Disclosures:
Faculty:

Ekhard Ziegler, M.D. has no financial interest in products or servces discussed.
Josef Neu, M.D. has no financial interest in products or servces discussed.
Philip Sherman, M.D., FRCPC, FAAP has no financial interest in products or servces discussed.

Planning Committee:
Kathleen Davis, MD, CME Committee, has no financial interest in products or services discussed.
George Gey, MD, CME Committee Chair, has no financial interest in products or services discussed.
Jeanette Dunn, RN, EdD, Exec. Director, has no financial interest in products or services discussed.


Accreditation:
This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the Foundation for Care Management (FCM) and Indicia Medical Education, LLC.

FCM is accredited by the ACCME to provide continuing medical education for physicians.

FCM designates this educational activity for a maximum of 1 AMA PRA Category 1 Credit™* Physicians should only claim credit commensurate with the extent of their participation in the activity.

The Foundation for Care Management is an approved provider of continuing nursing education by the Colorado Nurses Association, an accredited approver by the American Nurses Credentialing Center ’s Commission on Accreditation. Approval period: July 1, 2006 — June 30, 2009 . Provider # FCM-0303.

The Foundation for Care Management is accredited by the Accreditation Council for Pharmacy Education as a provider of continuing pharmacy education. Program # 347-999-08-055-H01-P.
* This CE activity is knowledge based (K).

This program has been approved by the Commission on Dietetic Registration for 1 CPEU

What you must do to obtain credit for this course
1. Review the faculty biosketches and disclosures
2. Read the objectives of the course
3. Review the Privacy statement
4. Take the brief Pre-test
5. Study the course narrative and view the slides
6. Review the references
7. Read and/or print out the handouts: A Primer on Prebiotics and Probiotics and Guide to the Use of Pre and Probiotics
8. Take the Post-test and course evaluation. At this time you will enter your demographic data for your permanent record
9. Print your certificate

Educational Need
The number of clinical trials (and meta-analyses of trials) that have studied the efficacy and safety of prebiotics and probiotics in the pediatric population has increased, and a promising role for their use has been indicated in pediatric disease states such as infantile and pediatric diarrhea, antibiotic-associated diarrhea, atopic dermatitis, rotavirus diarrhea, ulcerative colitis, and necrotizing enterocolitis (NEC) in preterm infants.

In addition, certain prebiotics and probiotics may also augment intestinal immune and cytoprotective responses in the developing intestine, as well as induce a bacterial colonization pattern in the gut of formula-fed infants that more resembles that of the breast-fed infant (i.e. a larger proportion of Bifidobacteria). Of note, preterm infants, who are often managed with broadspectrum antimicrobials, often fail to acquire commensal bacteria and have altered systemic and mucosal immune function; the use of probiotics in these populations has been used to prevent NEC through recapitulation of normal intestinal micobiota.

Educational Objectives
Upon completion of this activity, the heathcare provider should be better able to:

  • Discuss the functions and significance of intestinal microbiota
  • Explain the mechanism of action of prebiotics and probiotics and how they have been used effectively
  • Evaluate the benefits and risks associated with the use of prebiotics and probiotics
  • Recommend safe, effective, and appropriate prebiotic and probiotic formulae for specific neonatal and pediatric conditions based on current data

Proceed to the course material


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